Compartmentalized Human Immunodeficiency Virus Type 1 Reservoir in Intestinal Monocytes/Macrophages on Antiretroviral Therapy
Our results show that monocytes/macrophages from the intestinal mucosa of PWH on ART can contain HIV-1 DNA, including intact or unintegrated forms, but at much lower levels than those found in T cells, and with some compartmentalization, although they do not exhibit a specific macrophage tropism, raising the question of the mechanisms of infection involved.
Authors
- Nived Collercandy (ORCID: https://orcid.org/0000-0001-7026-2581)
- Karl Barange
- Guillaume Martin‐Blondel (ORCID: https://orcid.org/0000-0002-8363-7028)
- Justine Latour
- Camille Vellas (ORCID: https://orcid.org/0000-0002-8637-6695)
- Manon Nayrac (ORCID: https://orcid.org/0000-0001-5717-6232)
- Pierre Delobel (ORCID: https://orcid.org/0000-0002-2874-3581)
- Laurent Alric (ORCID: https://orcid.org/0000-0003-0676-7539)
- Bernard Lagane (ORCID: https://orcid.org/0000-0002-3459-7867)
- Jacques Izopet (ORCID: https://orcid.org/0000-0002-8462-3234)
- Mary Réquena
- Dorine Martres
Institutions
- Université Toulouse III - Paul Sabatier (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Institut de Virologie (FR)
- Service de la Santé Publique (CH)
- Hospital for Tropical Diseases (VN)
- RESTORE (FR)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1093/infdis/jiae557
- Citations
- 5
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47