Mechanism of MiR-145a-3p/Runx2 pathway in dexamethasone impairment of MC3T3-E1 osteogenic capacity in mice
The results indicated that dexamethasone impaired the osteogenic differentiation ability of MC3T3-E1 cells by inducing the up-regulation of miR-145a-3p expression. MiR-145a-3p inhibited the osteogenic differentiation ability of MC3T3-E1 cells by targeting and suppressing the expression level of Runx2 protein. Inhibition of miR-145a-3p levels significantly improved the osteogenic differentiation ability of MC3T3-E1 cells.
Authors
- Xing‐Hua Liao (ORCID: https://orcid.org/0000-0002-3800-2322)
- Tingrui Wu (ORCID: https://orcid.org/0000-0003-0428-367X)
- Yiren Chen (ORCID: https://orcid.org/0000-0003-3347-8695)
- Lijun Song (ORCID: https://orcid.org/0000-0002-5114-6494)
- Bo Wei (ORCID: https://orcid.org/0000-0002-1058-5888)
- Hang Wu (ORCID: https://orcid.org/0009-0001-8485-629X)
- Sicheng Ding
- Bin Xie (ORCID: https://orcid.org/0009-0001-5859-3289)
Institutions
- Guangdong Medical College (CN)
- Central People's Hospital of Zhanjiang (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1371/journal.pone.0309951
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.14