Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome

We propose that cancer-specific Wnt-regulated lncRNAs provide novel therapeutic opportunities to interfere with the Wnt pathway, which has so far defied effective pharmacological inhibition.

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Publication Details

Journal
Gut
Published
2024-11-19
DOI
https://doi.org/10.1136/gutjnl-2024-332752
Citations
4
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
1.14

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article

Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome

Kristiaan Lenos, Tulin Dadali, Oscar Bril, Vanesa Muncan et al.
4 citations
Gut
Cancer-related molecular mechanisms research
1.14
article

Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome

Kristiaan Lenos, Tulin Dadali, Oscar Bril, Vanesa Muncan, Nina E. de Groot, Wendy Broom, R. Adam, Nicolas Léveillé, Fabricio Loayza‐Puch, Sanne M. van Neerven, Lisanne E. Nijman, Francesca Paola Giugliano, Leandro F. Moreno, Monique A.J. van Eijndhoven, Adrian Logiantara, Clara C. Elbers, D. Michiel Pegtel, Sophie P. J. M. Vromans, Ekaterina Stepanova, Martin A. Maier, Steven Eleonora, Danny A. Zwijnenburg, Jan Koster, Laura Schwarzmueller
article en
4 citations

Abstract

We propose that cancer-specific Wnt-regulated lncRNAs provide novel therapeutic opportunities to interfere with the Wnt pathway, which has so far defied effective pharmacological inhibition.

GutVol. 74(4)
Alnylam Pharmaceuticals (United States) (US), German Cancer Research Center (DE), Heidelberg University (DE), Oncode Institute (NL), Amsterdam University Medical Centers (NL), Cancer Center Amsterdam (NL), University of Amsterdam (NL)
KWF Kankerbestrijding
Openalex Percentile: Top 20%
Cancer-related molecular mechanisms research
1.14
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