Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus
These findings demonstrated that Sema5A-PlexinA1 axis acts as a key mediator on Th17 differentiation, suggesting that Sema5A might be a novel therapeutic target in SLE.
Authors
- Xin Chen (ORCID: https://orcid.org/0000-0002-3447-8892)
- Lingjiang Zhu
- Jieying Xu
- Yuanji Dong (ORCID: https://orcid.org/0000-0003-1699-1569)
- Qi Cheng (ORCID: https://orcid.org/0000-0003-0720-3188)
- Yan Du (ORCID: https://orcid.org/0000-0003-2962-6907)
- Yifan Xie (ORCID: https://orcid.org/0000-0002-5970-1966)
- Li Hua
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s13075-024-03437-z
- Citations
- 3
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Science and Technology Program of Zhejiang Province