A Phase II Basket Trial of Dual Anti–CTLA-4 and Anti–PD-1 Blockade in Rare Tumors SWOG S1609: Vulvar Cancers
Ipilimumab plus nivolumab in vulvar cancers resulted in an objective response in 3 of 16 patients, all of whom had durable responses lasting over 1 year. Notably, two additional patients experienced durable stable disease and unconfirmed PR. Correlative studies to determine response and resistance markers are ongoing.
Authors
- Liam Il‐Young Chung (ORCID: https://orcid.org/0000-0001-6541-793X)
- Hye Sung Kim (ORCID: https://orcid.org/0000-0002-7256-7597)
- Elad Sharon (ORCID: https://orcid.org/0000-0002-0044-9719)
- Megan Othus (ORCID: https://orcid.org/0000-0001-8176-6371)
- Charles D. Blanke
- Christopher W. Ryan (ORCID: https://orcid.org/0000-0002-4259-1123)
- Helen X. Chen (ORCID: https://orcid.org/0000-0001-9959-8417)
- Razelle Kurzrock (ORCID: https://orcid.org/0000-0003-4110-1214)
- Robert P. Edwards (ORCID: https://orcid.org/0000-0003-0370-1390)
- Sandip Pravin Patel (ORCID: https://orcid.org/0000-0002-8387-4840)
- Young Kwang Chae (ORCID: https://orcid.org/0000-0003-1557-7235)
- Christine M. McLeod
- Jennifer Scalici (ORCID: https://orcid.org/0000-0001-7895-4291)
- HOWARD Z. STREICHER (ORCID: https://orcid.org/0000-0003-3683-9804)
- Lucy Corthell (ORCID: https://orcid.org/0000-0003-1970-3243)
Institutions
- Northwestern University (US)
- Oregon Health & Science University (US)
- University of Pittsburgh (US)
- Medical College of Wisconsin (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- USA Mitchell Cancer Institute (US)
- Fred Hutch Cancer Center (US)
- Piedmont Cancer Institute (US)
- Magee-Womens Hospital (US)
- Temple University Hospital (US)
- National Cancer Institute (US)
- Data Management (Italy) (IT)
- SWOG Cancer Research Network (US)
- Winship Cancer Institute
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1957
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Bristol-Myers Squibb
- AstraZeneca
- National Institutes of Health
- Genentech
- National Cancer Institute