Safety of GLP-1 Receptor Agonists and Other Second-Line Antidiabetics in Early Pregnancy
JAMA Intern Med. 2024;184(2):144–152. doi: 10.1001/jamainternmed.2023.6663 Metformin is the first-line treatment in T2D. However, more patients are taking second-line antidiabetic medications (ADMs) as well to achieve adequate glycemic control. In pregnancy, insulin has historically been used due to its safety profile and metformin administration is now also common. With the recent increased use of ADMs, unintended exposure in early pregnancy is occurring and the risk of major congenital malformations (MCMs) in the infant is unknown. This large multinational study looked at the use and safety of GLP-1 receptor agonists and other noninsulin ADMs early in pregnancy in comparison to insulin.
Authors
- Cordula Gabriel (ORCID: https://orcid.org/0000-0002-9891-4251)
- Sonia Hernández–Dı́az (ORCID: https://orcid.org/0000-0003-1458-7642)
- Lars J. Kjerpeseth (ORCID: https://orcid.org/0000-0002-2033-736X)
- Krista F. Huybrechts (ORCID: https://orcid.org/0000-0001-5805-8430)
- Elisabetta Patorno (ORCID: https://orcid.org/0000-0002-8809-9898)
- Mika Gissler (ORCID: https://orcid.org/0000-0001-8254-7525)
- Kari Furu (ORCID: https://orcid.org/0000-0003-2245-0179)
- Laura Pazzagli
- EW Seely
- C.E. Cesta
- Maarit K. Leinonen (ORCID: https://orcid.org/0000-0002-7631-4749)
- B.T. Bateman
- Helga Zoëga (ORCID: https://orcid.org/0000-0003-0761-9028)
- Ran S. Rotem (ORCID: https://orcid.org/0000-0002-8378-3287)
- Jacob Moysés Cohen
Institutions
- Karolinska Institutet (SE)
Publication Details
- Journal
- Obstetric Anesthesia Digest
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1097/01.aoa.0001080172.80285.5b
- Citations
- 2
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.17