Vitamin D can mitigate sepsis-associated neurodegeneration by inhibiting exogenous histone-induced pyroptosis and ferroptosis: Implications for brain protection and cognitive preservation
This study demonstrates that vitamin D exerts a neuroprotective effect against sepsis by attenuating histone-induced pyroptosis and ferroptosis. These findings highlight the potential therapeutic role of vitamin D supplementation in mitigating brain dysfunction associated with sepsis which needs for further investigation.
Authors
- Yingying Jiang (ORCID: https://orcid.org/0000-0001-9671-7548)
- Azeem Alam (ORCID: https://orcid.org/0000-0002-4339-6223)
- Yibing Sun
- Ruquan Han (ORCID: https://orcid.org/0000-0003-4335-8670)
- Shiwei Li (ORCID: https://orcid.org/0000-0002-7506-5779)
- Daqing Ma (ORCID: https://orcid.org/0000-0003-1235-0537)
- PU Zhi-lin (ORCID: https://orcid.org/0000-0003-2156-4764)
- Ming Sun (ORCID: https://orcid.org/0000-0002-8505-3958)
- Yuxuan Deng (ORCID: https://orcid.org/0009-0009-9733-6304)
- Hailin Zhao (ORCID: https://orcid.org/0000-0002-4736-5897)
- Jing Zhang
- Jinpiao Zhu
Institutions
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Children's Hospital of Zhejiang University (CN)
- Beijing Institute of Neurosurgery (CN)
- Chelsea and Westminster Hospital (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.bbi.2024.11.019
- Citations
- 7
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.64