Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species
Our findings highlight significant AA-induced alterations in the signaling network that regulates NK cell activity. As low expression of several NK cell receptors correlates with shorter OC patient survival, these findings suggest a functional linkage between AA, NK cell dysfunction and OC progression.
Authors
- Florian Finkernagel (ORCID: https://orcid.org/0000-0002-1141-7499)
- Raimund Dietze
- Andrea Nist (ORCID: https://orcid.org/0000-0002-7524-6801)
- Elke Pogge von Strandmann (ORCID: https://orcid.org/0000-0003-4785-9165)
- Thorsten Stiewe (ORCID: https://orcid.org/0000-0003-0134-7826)
- Mohamad K. Hammoud (ORCID: https://orcid.org/0000-0002-3019-7794)
- Johannes Graumann (ORCID: https://orcid.org/0000-0002-3015-5850)
- Rolf Müller (ORCID: https://orcid.org/0000-0002-1042-5665)
- Witold Szymański (ORCID: https://orcid.org/0000-0002-1202-3299)
- Celina Meena
- Nathalie Hoffmann
Institutions
- Philipps University of Marburg (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s12964-024-01940-z
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Philipps-Universität Marburg