Enantioselective gold/enzyme dual catalysis

• First review article on enantioselective gold/enzyme dual catalysis. • Efficient merging of carbophilic activation property of gold catalysts with enantio -inducing ability of enzymes. • Realizing novel reactivities under enantioselective gold/enzyme dual catalysis which remain unachievable by a single catalyst. • Highlights the effective measures undertaken to overcome the mutual quenching of gold catalysts and enzymes. Over the decades, enantioselective metal/enzyme dual catalysis has emerged as a dynamic area of research in asymmetric synthesis. By leveraging the unique reactivities of metal/enzyme dual catalysis, numerous transformations have been developed, primarily relying on metals such as Pd, Ru, Ir, Fe and Au. Among all transition metals, gold stands out as the catalyst of choice due to its soft π -acidic nature. The π -activation reactivities of gold catalysts have been strategically integrated with enzyme catalysis, thereby leading to highly enantioselective transformations that are unattainable via a single catalyst alone. This review endeavors to provide an overview of the advancements in enantioselective gold/enzyme dual catalysis.