The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling
Our study demonstrated that B7-H4 plays an important role in regulating β-cell mass and insulin secretion, which may shed new light on the development of novel strategies for T2D treatment.
Authors
- N. Wang
- Yingli Lu (ORCID: https://orcid.org/0000-0002-5117-1614)
- Yan Wang (ORCID: https://orcid.org/0000-0002-7744-4078)
- Yan Liu (ORCID: https://orcid.org/0000-0003-4565-4780)
- Zhen Qian
- Yuefeng Yu (ORCID: https://orcid.org/0009-0008-0201-9123)
- Junxue Wang (ORCID: https://orcid.org/0000-0003-0748-7504)
- Fangzhen Xia (ORCID: https://orcid.org/0000-0002-1069-0418)
- Xiaoyu Fang (ORCID: https://orcid.org/0000-0003-2726-149X)
- Ziteng Zhang (ORCID: https://orcid.org/0009-0001-0851-0502)
- Zhen Jian-cun (ORCID: https://orcid.org/0000-0002-7402-2865)
- Guoting Sun
Institutions
- Shanghai Jiao Tong University (CN)
- ShanghaiTech University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.molmet.2024.102069
- Citations
- 1
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- National Natural Science Foundation of China
- ShanghaiTech University