Restoration of follicular β-catenin signaling by mesenchymal stem cells promotes hair growth in mice with androgenetic alopecia
hUCMSCs promoted hair regeneration in AGA model mice. This was found to be dependent on reducing DPCs apoptosis, thereby relieving the inhibitory effects of DPCs on the growth of HFSCs. The activation of the Wnt/β-catenin signaling pathway was shown to play a crucial role in the promotion of hair growth by hUCMSCs in AGA mice.
Authors
- Yue Yang (ORCID: https://orcid.org/0000-0002-9359-3348)
- Yi Pan (ORCID: https://orcid.org/0000-0002-5742-3202)
- Jiakun Liu (ORCID: https://orcid.org/0009-0000-6890-4848)
- Yan Wang (ORCID: https://orcid.org/0000-0002-1257-6635)
- Yanfeng Zhang (ORCID: https://orcid.org/0000-0002-3859-3839)
- Fangfang Zhang (ORCID: https://orcid.org/0000-0003-2659-2561)
- Wenjing Yan (ORCID: https://orcid.org/0000-0001-7115-4486)
- 良樹 鷹津 (ORCID: https://orcid.org/0000-0002-4995-3553)
- Jianxing Liu (ORCID: https://orcid.org/0000-0002-2201-3887)
- Qianqian Jin
- Xuedong Xie
Institutions
- China Pharmaceutical University (CN)
- Cell Technology (China) (HK)
- State Key Laboratory of Natural Medicine
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s13287-024-04051-1
- Citations
- 15
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Higher Education Discipline Innovation Project