MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury
The research concluded that hUC-MSCs-derived HGF can inhibit PKA-Drp1pSer637-mitochondrial elongation via its receptor cMet to alleviate renal senescence and fibrosis in post-AKI.
Authors
- Xinru Guo (ORCID: https://orcid.org/0000-0002-9454-2315)
- Xumin Zheng
- Wanjun Shen
- Xuejing Ren
- Guangyan Cai (ORCID: https://orcid.org/0000-0001-8586-6353)
- Zhe Feng (ORCID: https://orcid.org/0000-0002-7851-8999)
- Qiuxia Han (ORCID: https://orcid.org/0000-0003-3646-4248)
- Kaiting Zhuang (ORCID: https://orcid.org/0000-0002-1184-3279)
- Cheng Xu (ORCID: https://orcid.org/0000-0003-4728-6336)
- Wenjuan Wang (ORCID: https://orcid.org/0000-0003-3863-9937)
- X. Chen (ORCID: https://orcid.org/0009-0006-2578-1415)
Institutions
- Capital Medical University (CN)
- Nankai University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s13287-024-04041-3
- Citations
- 5
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China