Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache
These results suggest that formoterol is dysregulates eCB tone to drive headache-like periorbital allodynic behaviors. These results could help inform preventative treatment options for individuals receiving formoterol, as well as provide information on the interaction between the eCB and adrenergic system.
Authors
- Ingrid L. Peterson (ORCID: https://orcid.org/0000-0001-7356-2395)
- Natalie E. Scholpa (ORCID: https://orcid.org/0000-0002-1234-5482)
- Sheng‐Joue Young (ORCID: https://orcid.org/0000-0003-3164-2949)
- Erika Liktor‐Busa
- Kelly L. Karlage
- Tally M. Largent‐Milnes (ORCID: https://orcid.org/0000-0001-7599-102X)
- Rick G. Schnellmann (ORCID: https://orcid.org/0000-0001-6226-6064)
Institutions
- University of Arizona (US)
- Arizona Science Center (US)
- Southern Arizona VA Health Care System (US)
- Center for Innovation (US)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s10194-024-01907-y
- Citations
- 3
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- U.S. Department of Veterans Affairs
- University of Arizona
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke