Interleukin-10 deficiency suppresses colorectal cancer metastasis by enriching gut Parabacteroides distasonis
These findings demonstrate the significance of IL-10 deficiency in suppressing CRC metastasis through the 4-HPPA-AHR-VEGFA axis mediated by gut P. distasonis, suggesting that P. distasonis or 4-HPAA supplementation could offer a promising therapeutic strategy for CRC metastasis prevention.
Authors
- Ping Lan (ORCID: https://orcid.org/0000-0002-8901-8498)
- Junli Gong (ORCID: https://orcid.org/0000-0002-4732-055X)
- Zhanhao Luo (ORCID: https://orcid.org/0009-0001-7743-9850)
- Qiang Zhang (ORCID: https://orcid.org/0000-0001-9779-4887)
- Lili Feng (ORCID: https://orcid.org/0000-0001-9459-6594)
- Chen Liu (ORCID: https://orcid.org/0009-0003-0430-6146)
- Zhen He (ORCID: https://orcid.org/0000-0001-8901-8167)
- Hongmin Li (ORCID: https://orcid.org/0000-0003-1794-8845)
- Jingyi Yang (ORCID: https://orcid.org/0000-0002-6204-4039)
- Dayi Liang (ORCID: https://orcid.org/0009-0000-2679-9963)
- Yanchun Xie (ORCID: https://orcid.org/0000-0002-7451-1976)
- Jing Yu
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.jare.2024.11.024
- Citations
- 7
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- National Natural Science Foundation of China
- National Postdoctoral Program for Innovative Talents
- Basic and Applied Basic Research Foundation of Guangdong Province