Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria
Our study revealed that the accumulation of mitochondrial abnormalities is the major cause of post-sepsis skeletal muscle weakness. Pharmacological protection of mitochondria during acute sepsis is a potential clinical treatment strategy to prevent post-sepsis muscle weakness.
Authors
- Alexander R. Keeble (ORCID: https://orcid.org/0000-0001-5895-4315)
- Daret K. St. Clair
- Zoltán Ungvári (ORCID: https://orcid.org/0000-0002-6035-6039)
- Allison M. Owen (ORCID: https://orcid.org/0000-0001-5623-4891)
- Meagan S. Kingren (ORCID: https://orcid.org/0000-0002-9262-2936)
- Timothy A. Butterfield (ORCID: https://orcid.org/0000-0002-8787-2148)
- Christopher S. Fry (ORCID: https://orcid.org/0000-0002-4207-6594)
- Samir P. Patel (ORCID: https://orcid.org/0000-0003-3291-8265)
- Hiroshi Saito (ORCID: https://orcid.org/0000-0003-1062-2025)
- Jodi M. Ogle
- Alyson M. Galvan-Lara
Institutions
- Semmelweis University (HU)
- University of Kentucky (US)
- Markey Cancer Center (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s10020-024-00982-w
- Citations
- 11
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- National Institutes of Health