The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements
All current diagnostic criteria assume each patient can mount the same neutrophil response to an implant-associated infection. However, the state of the MPS is of critical importance to accurate diagnosis of an implant-associated infection. A reduction in neutrophil recruitment and function mediated by the MPS may allow joint replacements with a dormant infection to be mischaracterized as uninfected, thus limiting the prognostic capabilities of all current diagnostic tests.
Authors
- Stuart B. Goodman (ORCID: https://orcid.org/0000-0002-1919-3717)
- Naomi L. Haddock (ORCID: https://orcid.org/0000-0002-2525-1450)
- Derek F. Amanatullah (ORCID: https://orcid.org/0000-0002-6203-5853)
- Z. Ngalo Otieno-Ayayo
- David W. Lowenberg (ORCID: https://orcid.org/0000-0001-6416-1063)
- William J. Maloney
- Ievgen Koliesnik (ORCID: https://orcid.org/0000-0003-1959-7954)
- Robert Manasherob (ORCID: https://orcid.org/0000-0002-3236-789X)
- Lyong Heo (ORCID: https://orcid.org/0000-0003-4158-9600)
- Shay Warren (ORCID: https://orcid.org/0000-0002-1272-7093)
- Prerna Arora (ORCID: https://orcid.org/0009-0000-0608-1989)
- Diasuke Furukawa
Institutions
- Palo Alto University (US)
- University of California, San Francisco (US)
- Rongo University (KE)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s12967-024-05866-5
- Citations
- 5
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Orthopaedic Research and Education Foundation
- Osteosynthesis and Trauma Care Foundation
- National Institutes of Health
- School of Medicine, Stanford University
- National Center for Advancing Translational Sciences