Dermatoscopy, reflectance confocal microscopy, and gene expression profile findings in Spark’s nevus

Spark’s nevus, originally described by A. Bernard Ackerman,1 is a melanocytic nevus that displays features of both Spitz and Clark’s (dysplastic) nevi. These nevi have been documented to present clinically as larger than 5 mm diameter, asymmetric, darkly pigmented, and/or multicolored, and typically located on the trunk or lower extremities of females.1,2 On histopathologic examination, Spark’s nevi demonstrate a combination of Spitzoid cytologic features (large epithelioid or spindled melanocytes with large nuclei and abundant cytoplasm) and Clark’s nevus architecture (elongated rete ridges, bridging of nests, and papillary dermal fibrosis).