Lipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion
The study revealed alterations in omega-6 fatty acids, CD36 transport, and AA downstream oxylipins in RSA, which in turn promote M1 macrophage polarization. Thus, this research has established a foundation for identifying potential biomarkers for, and providing novel insights into, the diagnosis and pathophysiology of RSA.
Authors
- Ruiqi Chang (ORCID: https://orcid.org/0000-0001-9803-6172)
- Ting-Li Han (ORCID: https://orcid.org/0000-0001-6011-7508)
- Shufang Chang (ORCID: https://orcid.org/0000-0001-5836-733X)
- H. Mousa (ORCID: https://orcid.org/0000-0001-5348-3833)
- Huijia Chen
- Jingcong Dai
- Ting Han (ORCID: https://orcid.org/0000-0003-4365-0479)
- Xiaojia Yang (ORCID: https://orcid.org/0000-0002-7634-3929)
- Richard D. Cannon (ORCID: https://orcid.org/0000-0002-5398-2066)
- Yang Yang (ORCID: https://orcid.org/0009-0004-1591-8903)
- ShanAn Chan
- Hao Liu
- Xin Wang (ORCID: https://orcid.org/0000-0002-6229-1945)
Institutions
- Agilent Technologies (United States) (US)
- Army Medical University (CN)
- University of Leicester (GB)
- Dalian Medical University (CN)
- University Hospitals of Leicester NHS Trust (GB)
- Daping Hospital (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Public Health Medical Center (CN)
- University of Otago (NZ)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e40515
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Chongqing Medical University
- Chongqing Municipal Education Commission