Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform
We found evidence that UDCA is associated with a lower hazard of COVID-19 related hospitalisation and death, support calls for clinical trials investigating UDCA as a preventative measure for severe COVID-19 outcomes.
Authors
- Angel Y. S. Wong (ORCID: https://orcid.org/0000-0002-8618-7333)
- Bang Zheng (ORCID: https://orcid.org/0000-0003-1814-6692)
- John Tazare (ORCID: https://orcid.org/0000-0002-7194-2615)
- Rachel J. Smith (ORCID: https://orcid.org/0000-0001-7142-0684)
- Karen Waller (ORCID: https://orcid.org/0000-0002-0530-3292)
- Seb Bacon (ORCID: https://orcid.org/0000-0002-6354-3454)
- Amir Mehrkar (ORCID: https://orcid.org/0000-0002-2098-1278)
- George F. Mells (ORCID: https://orcid.org/0000-0002-7962-5286)
- Christopher T. Rentsch (ORCID: https://orcid.org/0000-0002-1408-7907)
- Ruth Costello (ORCID: https://orcid.org/0000-0003-2709-6666)
- Ben Goldacre (ORCID: https://orcid.org/0000-0002-5127-4728)
- Anna Schultze
- Liang-Yu Lin (ORCID: https://orcid.org/0000-0003-4720-6738)
- Emily Herrett (ORCID: https://orcid.org/0000-0002-9425-644X)
- Laurie A. Tomlinson (ORCID: https://orcid.org/0000-0001-8848-9493)
- Viyaasan Mahalingasivam (ORCID: https://orcid.org/0000-0002-3157-1127)
- Brian MacKenna
Institutions
- The University of Sydney (AU)
- University of Cambridge (GB)
- Concord Repatriation General Hospital (AU)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Yale University (US)
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- National Health and Medical Research Council (AU)
Publication Details
- Journal
- Communications Medicine
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1038/s43856-024-00664-y
- Citations
- 1
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- Wellcome Trust
- UK Research and Innovation
- National Institute for Health and Care Research
- Medical Research Council