Lipoxin A4 improves cardiac remodeling and function in diabetes-associated cardiac dysfunction
These findings demonstrated that LXA<sub>4</sub> treatment attenuated the extent of cardiac inflammation in diabetic hearts, resulting in limited cardiac remodeling and improved LV diastolic function. This supports further exploration of LXA<sub>4</sub>-based therapy for the management of diabetic heart disease. The recent development of stable LXA<sub>4</sub> mimetics holds potential as a novel strategy to treat cardiac dysfunction in diabetes, paving the way for innovative and more effective therapeutic strategies.
Authors
- Rebecca H. Ritchie (ORCID: https://orcid.org/0000-0002-8610-0058)
- Cheng Xue Qin (ORCID: https://orcid.org/0000-0003-2169-2686)
- Helen Kiriazis (ORCID: https://orcid.org/0009-0009-6658-1489)
- Eoin Brennan (ORCID: https://orcid.org/0000-0003-4908-5474)
- Owen L. Woodman (ORCID: https://orcid.org/0000-0003-3759-1396)
- Muthukumar Mohan (ORCID: https://orcid.org/0000-0003-1044-146X)
- Peishen Zhao (ORCID: https://orcid.org/0000-0003-0185-0595)
- Phillip Kantharidis (ORCID: https://orcid.org/0000-0001-6260-1643)
- Mark Emmanuel Cooper (ORCID: https://orcid.org/0000-0001-7785-2488)
- Ting Fu (ORCID: https://orcid.org/0009-0003-0387-9962)
- Cameron J. Nowell (ORCID: https://orcid.org/0000-0002-8662-9840)
- Barbara K. Kemp‐Harper (ORCID: https://orcid.org/0000-0002-4669-4277)
- Madhura Bose
- Catherine Godson (ORCID: https://orcid.org/0000-0003-0655-1041)
- Minh Deo
Institutions
- University College Dublin (IE)
- Baker Heart and Diabetes Institute (AU)
- Discovery Institute (US)
- Australian Regenerative Medicine Institute (AU)
- Monash University (AU)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s12933-024-02501-x
- Citations
- 12
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.82
Funders
- Australian Government
- UCD Foundation
- Diabetes Australia
- National Heart Foundation of Australia
- Monash University
- State Government of Victoria
- Medical Research Council
- National Health and Medical Research Council