Ethical issues in vaccine trial participation by adolescents: qualitative insights on family decision making from a human papillomavirus vaccine trial in Tanzania
Existing models of decision-making help to understand dynamics between parents, adolescents and researchers but neglect the important wider social impacts and the fundamental nature of trust. Children's roles in discussions can be evaluated using the principles of consent: autonomy, freedom and information. Concepts such as relational autonomy help to explain mechanisms families use to negotiate complex consent decisions. Whilst interviewees supported the maintenance of legal parental consent, researchers must design consent processes centring the child to ensure that whole family decision-making processes are supported.
Authors
- Sílvia de Sanjosé (ORCID: https://orcid.org/0000-0002-5909-676X)
- Hilary Whitworth (ORCID: https://orcid.org/0000-0003-2353-2352)
- Kathy J. Baisley (ORCID: https://orcid.org/0000-0003-1849-6625)
- Kirstin Rebecca Mitchell (ORCID: https://orcid.org/0000-0002-4409-6601)
- Lucy Frost (ORCID: https://orcid.org/0000-0002-6972-263X)
- Richard Hayes (ORCID: https://orcid.org/0000-0002-1729-9892)
- Deborah Watson-Jones
- Ms Tusajigwe Erio
- Ms Graca Marwerwe
Institutions
- University of London (GB)
- International AIDS Vaccine Initiative (US)
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Mwanza Intervention Trials Unit (TZ)
- Barcelona Institute for Global Health (ES)
- University of Glasgow (GB)
Publication Details
- Journal
- BMC Medical Ethics
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s12910-024-01122-z
- Primary Topic
- Ethics and Legal Issues in Pediatric Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- National Institute for Health and Care Research
- University of Glasgow
- Medical Research Council
- European and Developing Countries Clinical Trials Partnership