Effect and underlying mechanism of a photochemotherapy dual-function nanodrug delivery system for head and neck squamous cell carcinoma
Treatment with PN + L or PND + L significantly inhibited the malignant progress of HNSCC cells, and the therapeutic effect of PND + L was significantly stronger than that of PN + L. The JNK signalling pathway is a key mechanism by which PN exerts its anti-HNSCC activity.
Authors
- Xiangpan Li
- Wo-Er Jiao
- Lizhi Wu (ORCID: https://orcid.org/0000-0003-3013-1434)
- Huimin Liu (ORCID: https://orcid.org/0000-0001-6224-5124)
- Chen Hua (ORCID: https://orcid.org/0000-0002-4868-9308)
- Qian Lin (ORCID: https://orcid.org/0000-0002-2491-8954)
- Shiming Chen (ORCID: https://orcid.org/0000-0002-1216-004X)
- You Zou
- Dongdong Yu (ORCID: https://orcid.org/0000-0002-6217-4167)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s12967-024-05855-8
- Citations
- 1
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- Fundamental Research Funds for Central Universities of the Central South University