Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling
Macrophage depletion with clodronate liposomes suppressed synovitis and reduced the number and activity of synovial MSCs, highlighting the significance of macrophage-derived Nampt and Spp1 signals in synovial MSC activation. These findings offer potential therapeutic strategies to promote joint tissue regeneration by enhancing beneficial signals between macrophages and synovial MSCs.
Authors
- Ichiro Sekiya (ORCID: https://orcid.org/0000-0002-6331-722X)
- Kentaro Endo (ORCID: https://orcid.org/0000-0003-4790-4632)
- Hayato Kodama
Institutions
- Tokyo Medical and Dental University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s41232-024-00361-2
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Tokyo Medical and Dental University
- Japan Society for the Promotion of Science