METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer
These findings present an epi-transcriptional mechanism that maintains Hippo-independent YAP1 signaling and plays a role in preserving the undifferentiated state of TNBC, which indicates the potential for targeting the LSD1-METTL14 axis to address TNBC stemness.
Authors
- Lingzhi Wu
- Yingtang Zhou (ORCID: https://orcid.org/0000-0002-8678-295X)
- Pumin Zhang (ORCID: https://orcid.org/0000-0003-4063-3008)
- Xupeng Bai (ORCID: https://orcid.org/0000-0001-5393-1405)
- Jiarui Liu (ORCID: https://orcid.org/0000-0003-1881-1971)
- Xiaojie Feng
Institutions
- Zhengzhou University (CN)
- Zhejiang Cancer Hospital (CN)
- Henan Cancer Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-11-20
- DOI
- https://doi.org/10.1186/s13046-024-03225-2
- Citations
- 10
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Henan Provincial Science and Technology Research Project
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province