Integrative transcriptome analysis reveals Serpine2 promotes glomerular mesangial cell proliferation and extracellular matrix accumulation via activating <scp>ERK1</scp> /2 signalling pathway in diabetic nephropathy
In summary, Serpine2 regulates MCs proliferation and ECM synthesis through activation of the ERK1/2 pathway, which is an important pathogenesis mechanism of DN. These findings offer fresh perspectives on the mechanisms of glomerulosclerosis in DN pathogenesis and may provide new targets for treating DN.
Authors
- Xin Li (ORCID: https://orcid.org/0000-0003-2525-9679)
- Hongyu Xiang (ORCID: https://orcid.org/0000-0003-4336-5774)
- Zhe Dai (ORCID: https://orcid.org/0000-0003-0321-0225)
- Ting Zheng (ORCID: https://orcid.org/0000-0001-9710-564X)
- Ruhao Yang
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1111/dom.16069
- Citations
- 7
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.37