Stannous fluoride protects gingival keratinocytes against infection and oxidative stress by Porphyromonas gingivalis outer membrane vesicles
SnF<sub>2</sub> not only kills bacteria, but also inhibits bacterial virulence factors, such as LPS and OMVs. SnF<sub>2</sub>, SnCl<sub>2</sub> and stannous-containing toothpastes can precipitate OMVs and LPS to in principle protect gingival keratinocyte cells from infection leading to inflammation and oxidative stress.
Authors
- Julie Ashe
- Sancai Xie
- Niranjan Ramji
- Cheryl S. Tansky
- Fei Gao (ORCID: https://orcid.org/0000-0002-1413-6027)
- Banothu Ramji (ORCID: https://orcid.org/0000-0002-3054-1524)
- Vighter Iberi (ORCID: https://orcid.org/0000-0003-0518-4729)
- Yiping Sun (ORCID: https://orcid.org/0000-0003-1864-3365)
- Aaron R Biesbrock
Institutions
- Procter & Gamble (United States) (US)
Publication Details
- Journal
- Frontiers in Dental Medicine
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fdmed.2024.1492369
- Citations
- 5
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.00