Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway
This study has verified that the extract of <i>Valeriana officinalis L.</i> is highly effective in enhancing atherosclerosis disease. The mechanism is suggested through the PGC-1α/Sirt3/Epac1 signaling pathway, which improves mitochondrial energy metabolism.
Authors
- Xuanhui He (ORCID: https://orcid.org/0000-0003-1952-5387)
- Bo Yao (ORCID: https://orcid.org/0009-0002-2225-9956)
- Hengwen Chen
- J Ma (ORCID: https://orcid.org/0000-0002-2058-431X)
- Qingzhi Ran
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Changchun University of Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fphar.2024.1483518
- Citations
- 3
- Primary Topic
- Medicinal Plant Extracts Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences