Transcriptional and post-transcriptional regulation of CARMN and its anti-tumor function in cervical cancer through autophagic flux blockade and MAPK cascade inhibition
CARMN exerts an anti-cancer effect in CC progression by inhibiting the Akt-mTOR and MAPK signaling pathways. rs12517403 and the YBX1/DHX9 complex are key mechanisms influencing its transcription and stability in CC cells. CARMN represents a promising biomarker for CC diagnosis and therapeutic target.
Authors
- Hua Jin (ORCID: https://orcid.org/0000-0001-9829-0306)
- Bingjia Yu
- Jingzhou Hu (ORCID: https://orcid.org/0000-0003-4402-3370)
- Dan Meng (ORCID: https://orcid.org/0000-0001-8588-0235)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-5046-9785)
- Yun Zheng
- Qianqian Xia
- Bo Ding (ORCID: https://orcid.org/0000-0001-9131-4563)
- Haohan Liu (ORCID: https://orcid.org/0000-0003-0750-9304)
- Mulong Du (ORCID: https://orcid.org/0000-0002-2733-6490)
- Juan Wang (ORCID: https://orcid.org/0000-0003-0767-5687)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-6682-9917)
- Xiuting Li (ORCID: https://orcid.org/0000-0002-3364-8191)
- Xue Chen (ORCID: https://orcid.org/0000-0001-7537-1525)
- Meilin Wang (ORCID: https://orcid.org/0000-0002-4996-958X)
- Xing Zhang (ORCID: https://orcid.org/0000-0003-1643-6362)
- Fengying Liu
- Shizhi Wang (ORCID: https://orcid.org/0000-0002-6083-6753)
- Yiran Lu (ORCID: https://orcid.org/0000-0002-4053-2365)
- Yamei Nie
- Wenjing Yan (ORCID: https://orcid.org/0000-0001-6534-8276)
- Evan Yi-Wen Yu (ORCID: https://orcid.org/0000-0001-7825-5087)
Institutions
- Shihezi University (CN)
- Nantong University (CN)
- Jiangsu Vocational College of Medicine (CN)
- Nantong Tumor Hospital (CN)
- Zhongda Hospital Southeast University (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1186/s13046-024-03229-y
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- National Natural Science Foundation of China