Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway
Ozone facilitated macrophage clearance of apoptotic cells, decreased neuroinflammation by activation of p-AMPK/Gas6/MerTK/SOCS3 signaling pathway, which may become an effective therapeutic approach for neuropathic pain after further clinical validation.
Authors
- Xinyue Xia
- Shirong Ruan
- Yinbing Pan
- Xueyou Tao
- Fan Hu (ORCID: https://orcid.org/0000-0003-3521-5696)
- Rumeng Jia
- Liang Hu (ORCID: https://orcid.org/0000-0002-0013-7440)
- Yishuai Liu
- Wentao Liu (ORCID: https://orcid.org/0000-0001-8732-7927)
- Qingyan Tian
- Kunmao Jiang
Institutions
- Yili Friendship Hospital (CN)
- Jiangsu Province Hospital (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1455771
- Citations
- 13
- Primary Topic
- Medical and Biological Ozone Research
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Natural Science Foundation of China