Comparative Analysis of IMT-P8 and LDP12 Cell-Penetrating Peptides in Increasing Immunostimulatory Properties of HIV-1 Nef-MPER-V3 Antigen
Altogether, the data indicated that Nef-MPER-V3 antigen in different formulations was effective in eliciting immune responses. This fusion protein has the high potency to induce both immunity arms, specifically when incorporated with IMT-P8, which showed priority to LDP12. Moreover, HP91 resulted in a greater humoral and cellular immune activation compared to HSP27. These findings suggest the potential of IMT-P8 as a superior delivery system for enhancing immune responses in vaccine development.
Authors
- Sahar Sabaghzadeh
- Mona Sadat Larijani (ORCID: https://orcid.org/0000-0003-3681-5319)
- Seyed Mehdi Sadat (ORCID: https://orcid.org/0000-0001-7739-179X)
- Shekoufa Jahedian
- Azam Bolhassani (ORCID: https://orcid.org/0000-0001-7363-7406)
Institutions
- Pasteur Institute of Iran (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
Publication Details
- Journal
- Protein and Peptide Letters
- Published
- 2024-11-19
- DOI
- https://doi.org/10.2174/0109298665337811241010104557
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00