Analysis of translatomic changes in the Ubqln2P497S model of ALS reveals that motor neurons express muscle-associated genes in non-disease states
Surprisingly, genes often reported to be muscle-specific, such as Desmin and Acta1, were expressed in motor neurons and were dramatically downregulated in symptomatic <i>Ubqln2<sup>P497S</sup></i> mice. The expression of muscle transcripts by motor neurons suggests their potentially supportive role in skeletal muscle maintenance.
Authors
- Wesley M. Stansberry (ORCID: https://orcid.org/0000-0003-0844-5103)
- Melissa M. Robins (ORCID: https://orcid.org/0000-0002-1653-6518)
- Brian A. Pierchala (ORCID: https://orcid.org/0000-0002-9844-1706)
- Natalie C. Fiur
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fneur.2024.1491415
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke