Microglia induce an interferon‐stimulated gene expression profile in glioblastoma and increase glioblastoma resistance to temozolomide
Here, we show that the IRDS signature, linked to chemo-resistance in other cancers, can be induced in glioblastoma by microglia. ISG genes and the microglia inducing the ISG expression could be promising novel therapeutic targets in glioblastoma.
Authors
- Bjarne Winther Kristensen (ORCID: https://orcid.org/0000-0002-6352-0826)
- Stephanie Kavan (ORCID: https://orcid.org/0000-0001-5272-2118)
- Morten Meyer (ORCID: https://orcid.org/0000-0002-9571-1336)
- Stine Asferg Petterson (ORCID: https://orcid.org/0000-0001-9963-7295)
- Mark Burton (ORCID: https://orcid.org/0000-0002-3782-5933)
- Rikke Frydendahl Sick Olsen
- Mia Dahl Sørensen (ORCID: https://orcid.org/0000-0002-0105-2940)
- Torben A. Kruse (ORCID: https://orcid.org/0000-0002-2460-6483)
- Mads Thomassen (ORCID: https://orcid.org/0000-0003-0078-1217)
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1111/nan.13016
- Citations
- 10
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.38
Funders
- Kræftens Bekæmpelse
- Sundhed og Sygdom, Det Frie Forskningsråd
- Novo Nordisk
- Odense Universitetshospital
- Syddansk Universitet
- Novo Nordisk Fonden
- KV Fonden
- Medical Research Council