Single prolonged stress induces behavior and transcriptomic changes in the medial prefrontal cortex to increase susceptibility to anxiety-like behavior in rats
Our findings suggest that SPS activates distinct transcriptional and molecular pathways in PL and IL cortices of mPFC, enabling differential coping mechanisms in response to the effects of traumatic stress. The enhanced enrichment of identified KEGG pathways in the PL and IL mPFC may underlie the anxiety-like behavior observed in susceptible rats.
Authors
- Dan Shen (ORCID: https://orcid.org/0000-0001-8655-0166)
- Xiaojian Jia
- Yan-Xue Xue (ORCID: https://orcid.org/0000-0003-2979-0045)
- Geng-Di Huang
- Javed Iqbal (ORCID: https://orcid.org/0000-0002-3005-4785)
- Mei Yang (ORCID: https://orcid.org/0000-0002-8340-1250)
Institutions
- Peking University (CN)
- Southern University of Science and Technology (CN)
- Shenzhen KangNing Hospital (CN)
- National Institutes for Food and Drug Control (CN)
- Shenzhen University Health Science Center (CN)
- Stony Brook University (US)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fpsyt.2024.1472194
- Citations
- 6
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province