MiR-99a-5p up-regulates LDLR and functionally enhances LDL-C uptake via suppressing PCSK9 expression in human hepatocytes
MiR-99a-5p potently downregulates the expression of PCSK9 by directly interacting with a target site in the human <i>PCSK9</i> 3'-UTR, thereby up-regulating LDLR and functionally enhancing LDL-C uptake in human hepatocytes. MiR-99a-5p could serve as an inhibitor of PCSK9 for treating hypercholesterolemia to inhibit atherosclerosis.
Authors
- Dian Gu (ORCID: https://orcid.org/0000-0001-7009-184X)
- Qiujing Zhou (ORCID: https://orcid.org/0000-0002-8708-2357)
- Shuhua Tan (ORCID: https://orcid.org/0000-0002-4992-8876)
- Chenxi Zhang (ORCID: https://orcid.org/0000-0001-8785-708X)
- Ying Liu (ORCID: https://orcid.org/0000-0002-6540-0473)
- Xuemei Chen (ORCID: https://orcid.org/0000-0001-7435-8556)
- Yaqiang Zhao
- Wenfeng Zhao (ORCID: https://orcid.org/0000-0003-2517-4747)
- Menglong Xu (ORCID: https://orcid.org/0000-0002-0087-5646)
- Wei J. Wang (ORCID: https://orcid.org/0000-0002-4848-7394)
Institutions
- China Pharmaceutical University (CN)
- State Key Laboratory of Natural Medicine
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fgene.2024.1469094
- Citations
- 3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- China Pharmaceutical University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Fund for Fostering Talents of Basic Science