Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis
This study identified shared and unique genetic factors causally associated with different asthma subtypes. In so doing, our study emphasizes the need to move beyond perceiving asthma as a singular condition to enable the development of therapeutic interventions that target sub-type specific causal genes.
Authors
- Roan E. Zaied (ORCID: https://orcid.org/0000-0001-5981-9940)
- Caroline Walker (ORCID: https://orcid.org/0000-0002-9210-7651)
- Sreemol Gokuladhas (ORCID: https://orcid.org/0000-0002-1685-0259)
- Justin Martin O'Sullivan (ORCID: https://orcid.org/0000-0003-2927-450X)
Institutions
- Agency for Science, Technology and Research (SG)
- Garvan Institute of Medical Research (AU)
- University of Auckland (NZ)
- Singapore Institute for Clinical Sciences (SG)
- Maurice Wilkins Centre (NZ)
- MRC Lifecourse Epidemiology Unit (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1412032
- Citations
- 2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.65