Omics techniques reveal the pathogenesis of microbial communities in asthma

Abstract. The presence of airway hyperresponsiveness in asthma provides the basis for constriction in bronchus response to a variety of stimuli, leading to limited airflow, dyspnea, wheezing, and chest tightness, threatening patients lives. Statistics have shown that asthma is more prevalent in the adolescents and children than in the adults, suggesting that early ecological dysregulation of the gut and airway microbiome contributes to the occurrence of asthma, especially in the preschool years children. With the development of high-throughput sequence technologies such as genomics, it has become possible to study the association of pathophysiological processes of allergic reactions and ecological dysregulation using the multi-omics techniques. In this review, the author first briefly introduces the classification of asthma, summarizes the pathogenesis of microorganisms in asthma, providing a new direction and ideas for the research of the pathogenesis, diagnosis, and treatment of asthma.