Alpha-1-antitrypsin as novel substrate for S. aureus’ Spl proteases – implications for virulence
We unraveled a new virulence trait of <i>S. aureus</i>, where SplD/E/F cleave and inactivate AAT while the cleavage product C36 inhibits NETosis.
Authors
- Sophie Austermeier (ORCID: https://orcid.org/0000-0002-1048-5983)
- Franziska Scherr (ORCID: https://orcid.org/0000-0003-0504-3723)
- Silva Holtfreter (ORCID: https://orcid.org/0000-0002-2672-8230)
- Franziska Hoffmann (ORCID: https://orcid.org/0000-0002-6872-924X)
- Lydia Kasper (ORCID: https://orcid.org/0000-0002-4552-7063)
- Goran Abdurrahman (ORCID: https://orcid.org/0000-0003-3066-9058)
- Michael Kiehntopf
- Barbara M. Bröker (ORCID: https://orcid.org/0000-0002-5020-8542)
- Ferdinand von Eggeling (ORCID: https://orcid.org/0000-0002-8062-6999)
- Martin Eberhardt (ORCID: https://orcid.org/0009-0006-2292-8856)
- Murthy N. Darisipudi (ORCID: https://orcid.org/0000-0002-3315-4570)
- Camille Saade (ORCID: https://orcid.org/0000-0003-2368-9480)
- Friedemann Börner
Institutions
- Friedrich-Loeffler-Institut (DE)
- Universitätsmedizin Greifswald (DE)
- Jena University Hospital (DE)
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1481181
- Citations
- 7
- Primary Topic
- Enzyme Production and Characterization
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- European Commission
- Deutsche Forschungsgemeinschaft