Analyzing single-cell transcriptome sequencing data reveals immunological mechanisms of microglia-associated diseases

Abstract. In recent years, researchers have increasingly focused on the role of microglia in various neurological disorders, such as multiple sclerosis (MS). The single-cell transcriptome sequencing technology has provided new opportunities to unravel the roles and immunological mechanisms of microglia in a variety of neurological diseases. In this paper, the author explored the mechanisms of microglia in diseases of central nervous system, such as MS by analyzing single-cell transcriptome sequencing data with R. The authors investigated the regulation of microglia activation by signaling pathways, the role of microglia in the pathogenesis of brain dysfunction. Data analysis by single-cell transcriptome sequencing provides new perspectives and understanding of the pathophysiology of related diseases, and new ideas and strategies for their treatment and prevention.