Protective effect of Shenqi Wenfei Formula against lipopolysaccharide/cigarette smoke-induced COPD in Rat based on gut microbiota and network pharmacology analysis
Treatment with SQWF was found to restore the imbalance of intestinal <i>g_Parabacteroides</i> in COPD and also regulate the expression of the ReLA and HDAC1 genes, thereby reducing pulmonary neutrophil extracellular traps and alleviating lung inflammation.
Authors
- Qian Xue (ORCID: https://orcid.org/0009-0007-8423-4419)
- Qinjun Yang (ORCID: https://orcid.org/0000-0002-2337-1790)
- Di Wu (ORCID: https://orcid.org/0000-0003-4359-3849)
- Jiabing Tong (ORCID: https://orcid.org/0000-0002-7168-2577)
- Zegeng Li (ORCID: https://orcid.org/0000-0003-1845-488X)
- Mengyao Shi
- Jinghui Xie
- Jie Zhu (ORCID: https://orcid.org/0000-0001-8508-5864)
- Yating Gao (ORCID: https://orcid.org/0000-0002-5309-7243)
- Xiao Ma (ORCID: https://orcid.org/0009-0000-3912-5351)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-11-19
- DOI
- https://doi.org/10.3389/fmicb.2024.1441015
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China