Exploring the antipyretic and anti-inflammatory mechanisms of Bai-Hu-Tang

Abstract. Bai-Hu-Tang (BHT), derived from the Treatise on Cold Damage, is a classic traditional Chinese medicine formula mainly used to treat fever symptoms caused by excessive heat in the Qi component. Modern medical research has shown that BHT has significant antipyretic effects and can inhibit inflammatory reactions. However, the antipyretic substance basis and mechanism of action of BHT are not fully understood. Although studies have revealed its inhibitory effect on inflammatory factors, there is still a lack of in-depth understanding of its molecular level regulatory mechanisms. This article explores the effects of BHT on antipyretic and anti-inflammatory signaling pathways through modern pharmacological methods. This article specifically analyzes the specific effects of the active ingredients of the main drugs in BHT formula on the relevant signaling pathways of antipyretic and anti-inflammatory effects, and systematically explains the antipyretic and anti-inflammatory mechanisms of BHT with multiple pathways and targets. This study not only provides scientific basis for the clinical application of BHT, but also provides reference for future research. However, further research is needed on the interaction between multiple components in BHT and their regulatory effects under different pathological conditions. Future research can focus on the efficacy evaluation of BHT in different inflammation models, as well as its impact on immune cell function, in order to provide more scientific support for the modernization and internationalization of traditional Chinese medicine.