Expression profiles of different cytokines in the pathogenesis of autoimmune diseases

Abstract. Autoimmune diseases(AID) have always been immune system diseases that affect millions of patients around the world no matter your race or age. Although the exact origins of most autoimmune diseases are still unknown, A growing body of research suggests that cytokines in vivo are closely related to the pathogenesis of autoimmune diseases. There are many kinds of cytokines that have been shown to contribute to one or even more kinds of AIDs. There are also many researches that focus on the relationship between a single cytokine and the pathogenesis of a specific type of AIDS. However, there are few overall discussions and summaries of the relationship between individual cytokines and common autoimmune diseases. Here, this review chooses the three most common AIDs: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and psoriasis, and talk about the relationship of their pathogenesis with main cytokines, including TNF-, IL-17, IL-1 and IL-6. By summarizing the relationship between these cytokines and the pathogenesis of these three types of autoimmune diseases, this review has a reference value for the clinical treatment and scientific research of these diseases, as it shows that some cytokines can work upstream and downstream of the same pathway.