DNA methylation, a key concept in epigenetics

Abstract. DNA methylation, histone modifications, and CpG islands intricately regulate gene expression. Understanding these epigenetic mechanisms provides insights into cellular identity and how their dysregulation contributes to cancer development. Unraveling these complexities opens avenues for therapeutic interventions aimed at restoring normal epigenetic patterns in cancer cells. In light of the potential for epigenetic therapies to restore normal gene activity and enhance treatment outcomes, this work intended to present an overview of the state of knowledge about DNA methylation and its implications for cancer therapy.