Effect of M6A methylation on T cell homeostasis

Abstract. The m6A methylation modification is a prevalent form of RNA modification in organisms, exerting its influence on gene expression. In recent years, there has been a gradual elucidation of the relationship between the physiological functions of m6A methylation modification and immune regulation, obesity, as well as malignant diseases such as tumors. Consequently, the study of m6A methylation modification has emerged as a focal point in current molecular biology research. This research focuses on the interaction between immune system homeostasis and m6A methylation alteration and the human immune system. It also describes the significant effects of three crucial regulatory proteins required for m6A methylation modification on the growth and differentiation of immune cells (T cells). This research provides a novel direction for future studies in immunology and disease pathology. However, there are still some research difficulties, for instance, a number of methyltransferases, demethylases, and recognition proteins control the alteration of m6A methylation, and the interaction and regulatory network among these proteins are not clear, so future research can focus on this direction.