Targeted treatment of gastric cancer and its pathogenic mechanism

Abstract. Gastric cancer (GC) is a malignant tumor with high morbidity and mortality in our country. The traditional treatment methods include operation, radiotherapy and chemotherapy. At present, it cannot be cured by traditional treatment. Targeted therapy is a treatment method for GC targeting specific targets. Currently, the main therapeutic targets developed include HER2, VEGF and EGFR. It has the advantages of less side effects and good efficacy, but it still has the defect of not fully covering the patient population. This paper mainly introduces targeted therapy of GC, an emerging treatment method, and obtains relevant information about the pathogenic mechanism and main drugs of its main targets HER2, VEGF and EGFR. By summarizing the above information, this paper hopes to provide reference for the future research of targeted therapy of GC and make contributions to the development of more new targets of GC in the future.