The role of genetics and biotechnology in Alzheimers Disease

Abstract. As the prevalence of Alzheimer's disease continues to rise globally, increasing numbers of researchers have explored methodologies for effective clinical treatment. The purpose of this literature review is to synthesize findings pertaining to the crucial aspects of Alzheimer's disease (AD) pathogenesis and treatment. The first part will introduce the different mechanisms of pathogenesis in Late-Onset Alzheimers Disease (LOAD) and will discuss the complex correlation between the genetic factor and the environmental factor causing AD. For the second section, this literature review will discuss the effectiveness of biotechnologies in preventing, detecting, and curing Alzheimers disease. Novel neuroimaging and fluid biomarker-based diagnostic techniques are permitting earlier disease detection than prior techniques allowed. Meanwhile, stem cell-based and other novel therapeutic strategies show preliminary evidence of possibly halting or even reversing neurodegeneration. Naturally, more robust clinical trials are still warranted to fully validate the safety and efficacy endpoints for these emerging interventions. Ongoing interdisciplinary collaboration remains essential to ultimately realizing this goal of enhancing the clinical management of Alzheimer's patients worldwide.