The anticoagulant ability of lumbrokinase and the advantages of different dosage forms

Abstract. As a traditional Chinese medicine, earthworms were found to have an effective thrombolytic effect in which lumbrokinase, an active ingredient, is now usually purified for the treatment of cardiovascular diseases. As a highly safe and easy-to-obtain drug, lumbrokinase is often administered in the form of enteric-coated tablets. However, there is still a lack of relevant research on the detailed molecular mechanism of lumbrokinases anticoagulant mechanism, the effectiveness and safety of long-term use, the interaction with other drugs, and the expansion and optimization of clinical applications. This paper analyzes the mechanism of action of lumbrokinase, the influencing factors of external conditions, the method of administration and the research of new drug delivery systems. It provides a reference for future research on the role and application prospects of lumbrokinase in anticoagulation. However, the specific molecular mechanism of action and clinical application issues have not been resolved. Future research can focus on the molecular mechanism of action and the efficiency and safety of clinical use of new drug systems.