The behavior change effect of Levetriacetam in absence seizure

Abstract. The absence seizure is characterized by loss of consciousness and appears as a 3-5 Hz spike wave like discharge in electroencephalography (EEG) recording. Levetiracetam mainly works on the SV2A molecule, which can mediate neurotransmitter release. Compared with other antipsychotics, levetriacetam has shown great tolerance, fewer side effects and great efficacy. However, levetriacetam may alter the patients cognition and behavior in two different directions, enhance the cognition or become more aggressive. This change does not relate to the dose intake or other factors, it may be associated with the personal trait dopaminergic related gene. One possible explanation for this is that the dopaminergic related gene that can impact a persons trait can determine the adverse effect of levetriacetam. Understanding the relationship between the levetiracetam (LEV), absence seizure and behavior change can improve the safety of LEV modification, in this paper, there is the discussion about the role of the dopamine in the absence seizure, LEV pharmocology and behavior change.