Advancing the frontiers of oncology: The promising horizon of CAR-T cell therapy for colon cancer

Abstract. In the changing field of cancer treatment, cancer immunotherapy shines as a promising method that uses the body's own immune system to fight against cancer. This review investigates how this therapy works and its possibilities, with special attention given to CAR-T cell therapy for colon cancer. We investigate why immune checkpoint inhibitors work, what happens when we use cancer vaccines and especially CAR-T cell therapy - showing their victories as well as difficulties encountered along the way particularly within solid tumor treatments. The future of CAR-T cell therapy in colon cancer and the current clinical trials to tackle these hurdles are explained thoroughly.