Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients
This study demonstrates that serum from hand OA and knee OA patients evokes diverse cellular signalling patterns that differentiates hand OA, knee OA and healthy controls. This underlines that the pathomolecular mechanisms of OA are likely significantly different between hand and knee OA, a finding that could lead to new insight into the pathobiology of OA endotypes and joint-specific therapies.
Authors
- Guus van den Akker (ORCID: https://orcid.org/0000-0002-7071-1487)
- Tim J. M. Welting (ORCID: https://orcid.org/0000-0001-8081-4466)
- E.L. Vitters (ORCID: https://orcid.org/0000-0001-8391-8068)
- Leo A. B. Joosten (ORCID: https://orcid.org/0000-0001-6166-9830)
- A. van Caam (ORCID: https://orcid.org/0000-0001-5473-4884)
- C.H.M. van den Ende (ORCID: https://orcid.org/0000-0002-4352-2824)
- Nathalie G. M. Thielen (ORCID: https://orcid.org/0000-0002-3245-7537)
- M. Neefjes
- Bas Housmans (ORCID: https://orcid.org/0000-0003-4428-7122)
- Charlotte Kaffa
- Peter M van der Kraan
Institutions
- Radboud University Nijmegen (NL)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Maastricht University Medical Centre (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Sint Maartenskliniek (NL)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-11-18
- DOI
- https://doi.org/10.1093/rheumatology/keae555
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek