Exploring the genetic associations and causal relationships between antibody responses, immune cells, and various types of breast cancer
This study utilized MR methods to analyze potential causal relationships between various antibody immune responses, immune cell types, and BC subtypes, identifying four potential regulatory mediation pathways. The findings of this study offer potential targets and research directions for virus-related and immunotherapy-related studies, providing a certain level of theoretical support. However, limitations such as GWAS sample size constraints and unclear specific pathophysiological mechanisms need further improvement and validation in future studies.
Authors
- Jiayi Chen (ORCID: https://orcid.org/0009-0008-9762-5133)
- Fei Ge (ORCID: https://orcid.org/0000-0002-2831-1295)
- Fuhong Gong
- Ruimin Liu (ORCID: https://orcid.org/0000-0003-3690-4178)
- Chenxi Wang (ORCID: https://orcid.org/0000-0002-1813-4299)
- Yang Yang (ORCID: https://orcid.org/0000-0001-5720-773X)
- Wenlin Chen (ORCID: https://orcid.org/0000-0001-8986-4064)
- Mengping Lin
- Jingge Miao
Institutions
- Peking University (CN)
- Kunming Medical University (CN)
- Peking University Cancer Hospital (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-11-19
- DOI
- https://doi.org/10.1038/s41598-024-79521-w
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Kunming Medical University